The Catechol-O-methyltransferase (COMT) is involved in the pain signaling pathway and can help predict pain tolerance.
Catechol-dependent functions can include- cardiovascular, cognitive, and pain processing.
Aids in breaking down- Catecholamine Neurotransmitters: dopamine, epinephrine, and norepinephrine. PGX drugs for- asthma, hypertension and Parkinson’s Disease. It inactivates these transmitters by adding catecholamine, which is donated by S-adenosyl methionine (SAM). SAM production is influenced by the methionine cycle in which the methylenetetrahydrofolate reductase (MTHFR) enzyme is the limiting step. Therefore, it is common for COMT and MTHFR to be talked about simultaneously.