The CYP1B1 gene encodes a member of the cytochrome p450 family of proteins.
CYP1B1 Location- inner membrane of mitochondria or in the endoplasmic reticulum of cells; liver microsomes; active in many tissues including: structures of the eye, fat, skin, breast gland, prostate, heart, blood vessels, kidney, thymus/marrow and immune cells, breast, uterus, brain.
The CYP1B1 enzyme is regulated by- the aryl hydrocarbon receptor.
CYP1B1 is involved in- NADPH-dependent electron transport pathway; oxidizes compounds including: fatty acids, steroids, retinoid, and xenobiotics; decreasing oxidative stress; hydroxylation of certain hormones such as estrogen; eye development; protection from cancer; increases fat uptake.
CYP1B1 metabolizes- fatty acids and fat-soluble vitamins; flavonoids, melatonin; polycyclic aromatic hydrocarbons (PAHs): aminoazo dyes, arylamines, biphenyls, N-heterocyclic amines, and other toxic environmental chemicals; retinol; steroid hormones: estrogens, cortisol, and aldosterone.
CYP1B1 deficiency- increases AMPK; reduces obesity; reduces blood pressure; improves glucose tolerance.
Decreases CYP1B1- Apigenin; Chrysoeriol (rooibos tea and celery); Ginseng; Lycopene; Naringenin (grapefruit juice); Quercetin; St. John’s wort; Zyflamend polyherbal in common herbs (rosemary, turmeric, ginger, holy basil, green tea, hu zhang, Chinese goldthread, barberry, oregano, and Baikal skullcap).
Increases CYP1B1- Biotin; Diesel exhaust particles (DEP); Tetrahydrocannabinol (THC) in cannabis; UV exposure.