Global hypomethylation in genomic DNA and hypermethylation are common in specific gene promoters occurring in cancers. Genomic instability can result in carcinogenesis from the p16 gene code for proteins for tumor suppression and O-6-Methylguanine-DNA Methyltransferase (MGMT) gene encodes an enzyme for DNA repair, the p16 gene is hypermethylated across many tumors; colorectal, lung and, breast carcinomas. Hereditary (mutagenic) factors and age-related (epigenic) changes have aided in the development of oral squamous cell carcinoma (OSCC). There is a link between C677T and development of several cancers, but DNA methylation in relation to age, diet and other environmental factors can also play a part 4.