The term, “epigenetics,” was first used to refer to the complex interactions between the genome and the environment that are involved in development and differentiation in higher organisms. Today, this term is used to refer to heritable alterations that are not due to changes in DNA sequence. Rather, epigenetic modifications, or “tags,” including DNA methylation and histone modification, alter DNA accessibility and chromatin structure, thereby regulating patterns of gene expression. These processes are crucial to normal development and differentiation of distinct cell lineages in the adult organism 6. Genetic polymorphisms in MTHFR genes alter the activity of the protein it encodes from a change in expression 12. MTHFR genes affected by two single-nucleotide substitutions result in changes of amino acids, mainly C667T and A1298C which can have varying significantly between different individuals. Gene polymorphisms of MTHFR enzyme affect available endogenous folate levels. The C677T enzyme affects thermal stability bring on a reduction of this enzyme. A 50% reduction in enzyme activity on TT677 results in increased concentrations of plasma homocysteine and unbalanced folate metabolites. A1298C polymorphism has a lesser effect on enzyme function but when combined with C677T polymorphism results in a higher reduction of MTHFR enzyme activity 12. When two polymorphisms are on the same gene it is known as a compound mutation.