A study by Wu, Yang, (2016) on MTHFR C677T and A1298C polymorphism and risk of polycystic ovary syndrome (PCOS) which is one of the most frequently encountered endocrine malfunctions with 15% of women of reproductive age suffering from this condition. Common symptoms of PCOS include; obesity, menstrual abnormalities, hair growth, high blood insulin and insulin resistance. They found C677T can influence Polycystic ovary syndrome, but A1298C was not associated 12.